D. K. Brubaker, J.A. Paulo, S. Sheth, E. J. Poulin, O. Popow, B. A. Joughin, S. D. Strasser, A. Starchenko, S. P. Gygi, D. A. Lauffenburger, K. M. Haigis. Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation. Cell Systems. 2019 Sep 11;

62. C.W. Johnson, Y-J. Lin, D. Reid, J. Parker, P. Dischinger, C. Graveel, S. Pavlopoulos, M. Steensma, K.M. Haigis. C. Mattos. Isoform-specific destabilization of the active site reveals molecular mechanism of intrinsic activation of KRas G13D. Cell Reports In Press. 2019 Aug 7;

61. O. Popow, J. Paulo, M. Tatham, M. Volk, A. Rojas-Fernandez, N. Loyer, I. Newton, J. Januschke, K. M. Haigis, and I. Nathke. Identification of endogenous Adenomatous polyposis coli interaction partners and beta-catenin-independent targets by proteomics. Mol. Cancer Res. 2019 Jun 3;

60. E. J. Poulin, A. K. Bera, J. Lu, Y. J Lin, S. D. Strasser, J. A. Paulo, T. Q.  Huang, C. Morales, W. Yan, J. Cook, J. A. Nowak, D. K. Brubaker, B. A Joughin, C. W. Johnson, R. A. DeStefanis, P. C. Ghazi, S. Gondi, T. E. Wales, R. E. Iacob, L. Bogdanova, J. J. Gierut, Y. Li, J. R. Engen, P. A. Perez-Mancera, B. S. Braun, S. P. Gygi, D. A. Lauffenburger, K. D. Westover and K. M. Haigis. Tissue-specific oncogenic activity of K-RasA146T. Cancer Discov. 2019 Apr 5;

59. K. M. Haigis, K. Cichowski, S.J. Elledge. Tissue-specificity in cancer: The rule, not the exception. Science. 2019 Mar 15; 363 (6432): 1150-1151

58. D. K. Brubaker, E. A. Proctor, K. M. Haigis, D. A. Lauffenburger. Computational translation of genomic responses from experimental model systems to humans. PLoS Comput. Biol. 2019 Jan 10;15(1):e1006286


57. L. Suarez-Lopez, G. Sriram, Y.W. Kong, S. Morandell, K.A. Merrick, Y. Hernandez, K.M. Haigis, M.B. Yaffe. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A. 2018 May 1; 115(18)

56. J. Lyons, P.C. Ghazi, A. Starchenko, A. Tovaglieri, K.R. Baldwin, E.J. Poulin, J.J. Gierut, C. Genetti, V. Yajnik, D. T. Breault, D.A. Lauffenburger, K.M. Haigis. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018 Mar 29;16(3)

55. J. Lyons, D.K. Brubaker, P.C. Ghazi, K.R. Baldwin, A. Edwards, M. Boukhali. S.D. Strasser, L. Suarez-Lopez, Y. Lin, V. Yajnik, J.L. Kissil, W. Haas, D.A. Lauffenburger, K.M. Haigis. Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Sci Signal. 11(519).

54. K.M. Haigis. KRAS Alleles: The Devil Is In the DetailTrends in Cancer. 3(10):686-697.


53. T.D. Martin, D.R. Cook, M.Y. Choi, M.Z. Li, K.M. Haigis, S.J. Elledge. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep. July 11, 2017.

52. E.J. Poulin and K.M. Haigis. No back seat for a progression event-K-RAS as a therapeutic target in CRC. Genes Dev. February 15, 2017.


51 V. Deshpande, I.T. Konstantindis, C.F. Castillo, A.F. Hezel, K.M. Haigis, D.T. Ting, N. Bardeesy, L. Goyal, A.X. Zhu, A.L. Warshaw, K.D. Lillemoe, C.R. Ferrone.  Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma.  J Gastrointest Surg.  First Online: March 8, 2016. 


50 J.J. Gierut, L.B. Wood, K.S. Lau, Y.J. Lin, C. Genetti, A.A. Samatar, D.A. Lauffenburger, K.M. Haigis.  Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium. Sci Signal. 8:ra129. 

49 L.B. Wood, A.R. Winslow, E.A. Proctor, D. McGuone, D.A. Mordes, M.P. Frosch, B.T. Hyman, D.A. Lauffenburger, K.M. Haigis.  Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening. Sci Rep. 5:16622.

48 B.N. Nicolay, P.S. Danielian, F. Kottakis, J.D. Lapek Jr, I. Sanidas, W.O. Miles, M. Dehnad, K. Tschöp, J.J. Gierut, A.L. Manning, R. Morris, K. Haigis, N. Bardeesy, J.A. Lees, W. Haas, N.J. Dyson. Proteomic analysis of pRb loss highlights a signature of decreased oxidative phosphorylation. Genes Dev. 29: 1875-1889.

47 J.J. Gierut, J. Lyons, M.S. Shah, C. Genetti, D.T. Breault, K.M. Haigis. 2015. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 15: 165-171.

46 K.M. Haigis and D.A. Lauffenburger, guest editors.  Themed Collection: In Vivo Systems Biology. Integr. Biol. 7.

45 P. Depeille, L. Henricks, R. van de Ven, E. Lemmens, C.Y. Wang, M. Matli, Z. Werb, K.M. Haigis, D. Donner, R. Warren, J.P. Roose. 2015. RasGRP1 opposes proliferative EGFR-SOS1 signals and restricts intestinal epithelial cell growth. Nat. Cell Biol. 17: 804-815.

44 R.H.F. Bender, K.M. Haigis, D.H. Gutmann. 2015. Activated K-Ras, but not H-Ras or N-Ras, regulates brain neural stem cell proliferation in a Raf/Rb-dependent manner. Stem Cells 33: 1998-2010.

43 F.D. Tsai, M.S. Lopes, M. Zhou, H. Court, O. Ponce, J.J. Fiordalisi, J.J. Gierut, A.D. Cox, K.M. Haigis, M.R.  Philips. 2015. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proc. Natl Acad. Sci. USA 112: 779-784.


42 M.R. Burgess, E. Hwang, A.J. Firestone, T. Huang, J. Xu, J. Zuber, N. Bohin, T. Wen, S.C. Kogan, K.M. Haigis, D. Sampath, S. Lowe, K. Shannon, Q. Li.  2014, Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood 124: 3947-3955.

41 H.J. Jun, J. Roy, T.B. Smith, L.B. Wood, K. Lane, S. Woolfenden, D. Punko, R.T. Bronson, K.M. Haigis, S. Breton, A. 2014. Charest. ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology 155: 3661-367.

40 Y. Imamura, P. Lochhead, M. Yamauchi, A. Kuchiba, Z.R. Qian, X. Liao, R. Nishihara, S. Jung, K. Wu, K. Nosho, Y.E. Wang, S. Pen, A.J. Bass, K.M. Haigis, J.A. Meyerhardt, A.T. Chan, C.S. Fuchs, S. Ogino. 2014. Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review. Mol. Cancer 21: 135.

39 A.L. Russo, D.R. Borger, J. Szymonifka, D.P. Ryan, J.Y. Wo, L.S. Blaszkowsky, E.L. Kwak, J.N. Allen, R.C. Wadlow, A.X. Zhu, J.E. Murphy, J.E. Faris, D. Dias-Santagata, K.M. Haigis, L.W. Ellisen, A.J. Iafrate, T.S. Hong. 2014. Mutational analysis and clinical correlation of metastatic colorectal cancer. Cancer 120: 1482-1490.

38 A.L. Russo, D.P. Ryan, D.R. Borger, J.Y. Wo, J. Szymonifka, W.Y. Liang, E.L. Kwak, L.S. Blaszkowsky, J.W. Clark, J.N. Allen, A.X. Zhu, D.L. Berger, J.C. Cusack, H.J. Mamon, K.M. Haigis, T.S. Hong. 2014. Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer. J. Gastrointest. Canc. 45: 34-39. 


37 L.B. Kleiman, A.M. Krebs, S.Y.Kim, T.S.Hong, K.M. Haigis. 2013. Comparative Analysis of Radiosensitizers for K-RAS Mutant Rectal Cancers. PLoS One. doi: 10.1371/journal.pone.0082982.  [pdf] 

36 K.S. Lau, S. Schrier, J. Gierut, J. Lyons, D.A. Lauffenburger, K.M. Haigis. 2013. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Integr. Biol. 5: 1355-1365. 

35 J. Xu, K.M. Haigis, A.J. Firestone, M.E. McNerney, Q. Li, E. Davis, S.C. Chen, J. Nakitandwe, J. Downing, T. Jacks, M.M. Le Beau, K. Shannon. 2013. Dominant role of oncogenic dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer. Disc. 3: 993-1001. 

34 M.H. Yang, G. Laurent, A.S. Bause, R. Spang, N. German, M.C. Haigis, K.M. Haigis. 2013. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol Cancer Res. doi: 10.1158/1541-7786.MCR-13-0040-T. 

33 E.R. Miraldi, H. Sharfi, R.H. Friedline, H. Johnson, T. Zhang, K.S. Lau, H.J. Ko, T.G. Curran, K.M. Haigis, M.B. Yaffe, R. Bonneau, D.A. Lauffenburger, B.B. Kahn, J.K. Kim, B.G. Neel, A. Saghatelian, F.M. White. 2013. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr. Biol. 5: 940-963

32 H. Cho, T. Hashimoto, E. Wong, Y. Hori, L.B. Wood, L. Zhao, K.M. Haigis, B.T. Hyman, D. Irimia. 2013. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-b on microglial accumulation. Sci. Rep. 3:1823. 

31 Y. Wang, S. Velho, E. Vakiani, S. Peng, A.J. Bass, G.C. Chu, J. Gierut, J.M. Bugni, C.J. Der, M.Philips, D.B. Solit, K. M. Haigis. 2012. Mutant N-Ras protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discovery. Published online first doi: 10.1158/2159-8290.CD-12-0198.  


30 D. Mitra, X. Luo, A. Morgan, J. Wang, M.P. Hoang, J. Lo, C.R. Guerrero, J.K. Lennerz, M.C. Mihm, J.A. Wargo, K.C. Robinson, S.P. Devi, J.C. Vanover, J.A. D'Orazio, M. McMahon, M.W. Bosenberg, K.M. Haigis, D.A. Haber, Y. Wang, D.E. Fisher. 2012. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 491: 449-452.  

29 K.S. Lau, V. Cortez-Retamozo, S.R. Philips, M.J. Pittet, D. A. Lauffenburger, K.M. Haigis. 2012. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. PLoS Biology. 10(9): e1001393. [data set] 

28 Y. Imamura, T. Morikawa, X. Liao, P. Lochhead, A. Kuchiba, M. Yamauchi, Z.R. Qian, R. Nishihara, J.A. Meyerhardt, K.M. Haigis, C.S. Fuchs, S. Ogino. 2012. Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers. Clin Cancer Res. in press. 

27 K.S. Lau, T. Zhang, K.R. Kendall, D. Lauffenburger, N.S. Gray, K.M. Haigis. 2012. BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner. PLoS One. 7(7):e41343

26 M.H. Yang, S. Nickerson, E.T. Kim, C. Liot, G. Laurent, R. Spang, M.R. Philips, Y. Shan, D.E. Shaw, D. Bar-Sagi, M.C. Haigis, K.M. Haigis. 2012. Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci. 109(27):10843-8

25 A.E. Powell, Y. Wang, Y. Li, E.J. Poulin, A.L. Means, M.K. Washington, J.N. Higginbotham, A. Juchheim, N. Prasad, S.E. Levy, Y. Guo, Y. Shyr, B.J. Aronow, K.M. Haigis, J.L. Franklin, R.J. Coffey. 2012.The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149(1):146-58. 

24 J. Xu, C. Hedberg, F.J. Dekker, Q. Li, K.M. Haigis, E. Hwang, H. Waldmann,K. Shannon. 2011.Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood. 119(4):1032-5. 

23 K.S. Lau, A.M. Juchheim, K.R. Cavaliere, S.R. Philips, D.A. Lauffenburger, and K.M. Haigis. 2011. In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-{alpha}-Induced Apoptosis and Proliferation by MAPKs. Sci. Signal. 4:ra16 [data set] 


22 Q. Li, K.M. Haigis, A. McDaniel, E. Harding-Theobald, S.C. Kogan, K. Akagi, J.C.Y. Wong, B.S. Braun, L. Wolff, T. Jacks, and K.M. Shannon. 2011. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood 117:2022-32. 

21 N. Tanaka, C. Huttenhower, K. Nosho, Y. Baba, K. Shima, J. Quackenbush, K.M. Haigis, E. Giovannucci, C.S. Fuchs, and S. Ogino. 2010. Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. Am. J. Pathol. 177: 2731-2740. 

20 P.K. Kreeger, Y. Wang, K.M. Haigis, and D.A. Lauffenburger. 2010. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integr. Biol. 2: 202-208. 

19 D.G. Kirsch, P.M. Santiago, E. di Tomasso, J.M. Sullivan, W-S. Hou, T. Dayton, L.B. Jeffords, P. Sodha, K. Mercer, R. Cohen, O. Takeuchi, S.J. Korsmeyer, R. Bronson, C.F. Kim, K.M. Haigis, R.K. Jain, and T. Jacks. 2010. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 327: 593-596. 

18 A.F. Cheung, A.M. Carter, K.K. Kostova, J.F. Woodruff, D. Crowley, R.T. Bronson, K.M. Haigis, and T. Jacks. 2010. Complete deletion of Apc results in severe polyposis in mice. Oncogene 29: 1857-1864. 

17 N. Irahara, Y. Baba, K. Nosho, K. Shima, L. Yan, D. Dias-Santagata, A.J. Iafrate, C.S. Fuchs, K.M. Haigis, and S. Ogino. 2010. NRAS mutations are rare in colorectal cancer. Diag. Mol. Path. 19:157-163. 

2010 and before

16 P.K. Kreeger, R. Mandhana, S.K. Alford, K.M. Haigis, and D.A. Lauffenburger. 2009. RAS mutations impact TNF-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits with non-ERK pathway effects. Cancer Res. 69: 8191-8199. 

15 K.S. Matharu, E. Mizoguchi, C.A. Cotoner, D.D. Nguyen, B. Mingle, O.I. Iweala, M.E. McBee, A.T. Stefka, G. Prioult, K.M. Haigis, A.K. Bhan, S.B. Snapper, H. Murakami, D.B. Schauer, H-C. Reinecker, A. Mizoguchi, and C.R. Nagler. 2009. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10 deficient mice. Gastroenterology 137: 1380-1390. 

14A. Ianari, T. Natale, E. Calo, E. Ferretti, E. Alesse, I. Screpanti, K. Haigis, A. Gulino, and J.A. Lees. 2009 Pro-apoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell 15:184-194. 

13 E.J. Morris, J-Y Ji, F. Yang, L. Di Stefano, A. Herr, N-S Moon, E-J Kwon, K.M. Haigis, A.M. Näär, and N.J. Dyson. 2008. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 455: 552-556. 

12 K.M. Haigis, K.R. Kendall, Y. Wang, A. Cheung, M.C. Haigis, J.N. Glickman, M. Niwa-Kawakita, A. Sweet-Cordero, J. Sebolt-Leopold, K.M. Shannon, J. Settleman, M. Giovannini, and T. Jacks. 2008. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nature Genetics 40:600-608. 

11 J.L. Kissil, M.J. Walmsley, L. Hanlon, K.M. Haigis, C.F. Bender Kim, A. Sweet-Cordero, M.S. Eckman, D.A. Tuveson, A.J. Capobianco, V.L. Tybulewicz, and T. Jacks. 2007. Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Research 67: 8089-8094. 

10 L.N. Kwong, K.R. Weiss, K.M. Haigis, and W.F. Dove. 2008. Atm is a negative regulator of intestinal neoplasia. Oncogene 27:1013-1018. 

9 T. Poutahidis, K.M. Haigis, V.P. Rao, P.R. Nambiar, C.L. Taylor, Z. Ge, A. Davidson, B.H. Horwitz, J.G. Fox, and S.E. Erdman. 2007. Rapid reversal of epithelial invasion in a mouse model of microbially-induced carcinoma. Carcinogenesis 28:2614-2623. 

8 S. Kaiser, Y.K. Park, J.L. Franklin, R.B. Halberg, M. Yu, W.J. Jessen, J. Freudenberg, X. Chen, K. Haigis, A.G. Jegga, S. Kong, B. Sakthivel, H. Xu, T. Reichling, M. Azhar, G.P. Boivin, R.B. Roberts, A.C. Bissahoyo, F. Gonzales, G.C. Bloom, S. Eschrich, S.L. Carter, J.E. Aronow, J. Kleimeyer, M. Kleimeyer, V. Ramaswamy, S.H. Settle, B. Boone, S. Levy, J.M. Graff, T. Doetschman, J. Groden, W.F. Dove, D.W. Threadgill, T.J. Yeatman, R.J. Coffey, and B.J. Aronow. 2007. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biology 8: R131. 

7 J.W. Keller, K.M. Haigis, J.L. Franklin, R.H. Whitehead, T. Jacks, and R.J. Coffey. 2007. Oncogenic K-RAS subverts the anti-apoptotic role of N-RAS and alters the N-RAS:gelsolin interaction. Oncogene 26:3051-3059. 

6 M.C. Haigis, R. Mostoslavsky, K.M. Haigis, K. Fahie, D.C. Christodoulou, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, M. Karow, G. Blander, C. Wolberger, T.A. Prolla, R. Weindruch, F.W. Alt, and L. Guarente. 2006. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126: 941-954. 

5 K. Haigis, J. Sage, J. Glickman, S. Shafer, and T. Jacks. 2006. The related retinoblastoma (Rb) and p130 genes cooperate to regulate homeostasis in the intestinal epithelium. Journal of Biological Chemistry 281:638-647. 

4 K.M. Haigis, P.D. Hoff, A. White, A.R. Shoemaker, R.B. Halberg, and W.F. Dove. 2004. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc. Natl. Acad. Sci. USA 101: 9769-9773. 

3 K.M. Haigis and W.F. Dove. 2003. A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nature Genetics 33: 33-39. 

2 K.M. Haigis, J.G. Caya, M. Reichelderfer, and W.F. Dove. 2002. Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proc. Natl. Acad. Sci. USA 99: 8927-8931. 

1 A.R. Shoemaker, K.M. Haigis, S.M. Baker, S. Dudley, R.M. Liskay, and W.F. Dove. 2000. Mlh1 deficiency enhances several phenotypes of ApcMin/+ mice. Oncogene 19: 2774-2779. 



10 J.J. Gierut, T.E. Jacks, and K.M. Haigis. Whole-mount X-Gal staining of mouse tissues. 2014. Cold Spring Harb. Protocol. 2014: 417-419.

9 J.J. Gierut, T.E. Jacks, and K.M. Haigis. Strategies to achieve conditional gene mutation in mice. 2014. Cold Spring Harb. Protocol. 2014: 339-349.

8 J.J. Gierut, T.E. Jacks, and K.M. Haigis. In vivo delivery of lenti-cre into mice using intranasal instillation. 2014. Cold Spring Harb. Protocol. 2014: 307-309. 

7 T. J.J. Gierut, T.E. Jacks, and K.M. Haigis. Producing and concentrating lenti-cre for mouse infections. 2014. Cold Spring Harb. Protocol. 2014: 304-306.

6 T.S. Hong, J.W. Clark, and K. Haigis. 2012. Cancers of the colon and rectum: identical or fraternal twins? Cancer Discov. 2: 177-121. 

5 I.M. Ahearn, K. Haigis, D. Bar-Sagi, and M.R. Philips. 2011. Regulating the regulator: Post-translational modification of Ras. Nat. Rev. Mol. Cell. Biol. 13: 39-51. 

4 S. Velho and K.M. Haigis. 2011. Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras. Exp. Cell. Res. 317: 2732-2739. 

3 K.M. Haigis and A. Sweet-Cordero. 2011. New insights into oncogenic stress. Nat. Genet. 43: 177-178. 

2 K.S. Lau and K.M. Haigis. 2009. Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Mol. Cells 28: 315-320. 

1 K.M. Haigis, I.I. Wistuba, and J.M. Kurie. 2007. Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question. Genes Dev. 21: 361-366. 



1 K.M. Haigis. 2013. Molecular Pathogenesis of Colorectal Cancer. Springer, New York.




© 2012-2019 Haigis Lab

© 2012-2019 Haigis Lab